Copper Diethyldithiocarbamate as an Inhibitor of Tissue Plasminogen Activator Synthesis in Cultured Human Coronary Endothelial Cells

Tomoya Fujie, Shiori Okino, Eiko Yoshida, Chika Yamamoto, Hiroshi Naka, and Toshiyuki Kaji

J. Toxicol. Sci. in press (2017).


Catalytic Transformation of Functionalized Carboxylic Acids Using Multifunctional Rhenium Complexes.

Masayuki Naruto, Santosh Agrawal, Katsuaki Toda, and Susumu Saito

Sci. Rep. 7, 3425 (2017). (doi: 10.1038/s41598-017-03436-y)



Multifaceted Catalytic Hydrogenation of Amides via Diverse Activation of a Sterically Confined Bipyridine–Ruthenium Framework

T. Miura, M. Naruto, K. Toda, T. Shimomura, and S. Saito

Sci. Rep. 7, 1586 (2017), (DOI: 10.1038/s41598-017-01645-z)[解説]


A Versatile Synthesis of Triarylantimony Difluorides by Fluorination of Triarylstibanes with Nitrosyl Tetrafluoroborate and Their Antitumor Activity

Yuki Kitamura, Mio Matsumura, Yuki Murata, Mizuki Yamada, Naoki Kakusawa, Motohiro Tanaka, Hiroyuki Okabe, Hiroshi Naka, Tohru Obata, and Shuji Yasuike

J. Fluorine Chem. in press (2017). (doi:


Dehydrogenation of Primary Aliphatic Alcohols by Au/TiO2 Photocatalysts

Masaki Shibata, Ryoko Nagata, Susumu Saito, and Hiroshi Naka

Chem. Lett. 46, 580–582 (2017). (doi: 10.1246/cl.161195)
[◀︎ Open Access] [Free PDF] [Overview]



Investigation of the Corey Bromolactamization with N-Functionalized Allylamines

Adrian Schulte, Simon Janich, Ernst-Ulrich Würthwein, Susumu Saito, and

Bernhard Wünsch

J. Heterocycl. Chem., Early view (2016).(doi: 10.1002/jhet.2493)


Stereoselective Synthesis of cis, cis-Configured Perhydroquinoxaline-5-carbonitrile from Cyclohex-2-en-1-ol

Adrian Schulte, Susumu Saito, and Bernhard Wünsch

J. Heterocycl. Chem., 53, 533–536 (2016). (doi: 10.1002/jhet.2322)


Synthesis of Morphan Derivatives with Additional Substituents in 8-Position.

Janine Stefaowitz, Dirk Schepmann, Constantin Daniliuc, Susumu Saito, and Bernhard Wünsch

Zeitschrift für Naturforschung B, 71, 1057–1069 (2016). (doi:10.1515/znb-2016-0129).


Versatile Ruthenium Complex “RuPCY” for Directed Catalytic Hydrogen Management in Organic Synthesis

Yuki Takada, Megumi Iida, Kazuki Iida, Takashi Miura, and Susumu Saito

J. Syn. Org. Chem. Jpn. (Invited English Account), 74, 1078–1088 (2016).


Selective Hydrogenation of Arenes to Cyclohexanes in Water Catalyzed by Chitin-Supported Ruthenium Nanoparticles

Yuna Morioka, Aki Matsuoka, Kellie Binder, Benjamin R. Knappett, Andrew E. H. Wheatley, and Hiroshi Naka
Catal. Sci. Technol. 6, 5801–5805 (2016) (doi: 10.1039/C6CY00899B).

[◀︎ Open Access] [Free PDF] [Overview]


Copper Diethyldithiocarbamate as an Activator of Nrf2 in Cultured Vascular Endothelial Cells

Tomoya Fujie, Masaki Murakami, Eiko Yoshida, Tadashi Tachinami, Yasuhiro Shinkai, Yasuyuki Fujiwara, Chika Yamamoto, Yoshito Kumagai, Hiroshi Naka, and Toshiyuki Kaji

J. Bio. Inorg. Chem. 21, 263–273 (2016). (doi: :10.​1007/​s00775-016-1337-z)

[◀︎ Open Access] [Free PDF] [Overview]


Induction of Metallothionein Isoforms by Copper Diethyldithiocarbamate in Cultured Vascular Endothelial Cells

Tomoya  Fujie, Yukino  Segawa, Tomoki  Kimura, Yasuyuki  Fujiwara, Chika  Yamamoto, Masahiko  Satoh, Hiroshi Naka, and Toshiyuki Kaji

J. Toxicol. Sci. 41, 225–232 (2016). (doi: 10.2131/jts.41.225) [◀︎ Open Access] [Free PDF]


Zinc Diethyldithiocarbamate as an Inducer of Metallothionein in Cultured Vascular Endothelial Cells

Tomoya Fujie, Yukino Segawa, Akane Uehara, Takehiro Nakamura, Tomoki Kimura, Eiko Yoshida, Chika Yamamoto, Masanobu Uchiyama, Hiroshi Naka, and Toshiyuki Kaji

J. Toxicol. Sci. 41, 217–224 (2016). (doi: 10.2131/jts.41.217) [◀︎ Open Access] [Free PDF]


Development of an Axially Chiral sp3P/sp3NH/sp2N-Combined Linear Tridentate Ligand—fac-Selective Formation of Ru(II) Complexes and Application to Ketone Hydrogenation
Tomoya Yamamura, Satoshi Nakane, Yuko Nomura, Shinji Tanaka, and Masato Kitamura

Tetrahedron 72, 3781-3789 (2016). (doi:10.1016/j.tet.2016.02.007)



Cationic Mononuclear Ruthenium Carboxylates as Catalyst Prototypes for Self-induced Hydrogenation of Carboxylic Acids

Masayuki Naruto and Susumu Saito

Nat. Commun. 6, 8140 (2015). (doi: 10.1038/ncomms9140) [◀︎ Open Access] [Overview]

N-Methylation of Amines with Methanol at Room Temperature

Vasily N. Tsarev, Yuna Morioka, Joaquim Caner, Qing Wang, Richiro Ushimaru, Akihiko Kudo, Hiroshi Naka, and Susumu Saito

Org. Lett. 17, 2530–2533 (2015). (doi: 10.1021/acs.orglett.5b01063) [Overview]



Hydration of Nitriles to Amides by a Chitin- supported Ruthenium Catalyst

Aki Matsuoka, Takahiro Isogawa, Yuna Morioka, Benjamin R. Knappett, Andrew E. H. Wheatley, Susumu Saito, and Hiroshi Naka

RSC Adv. 5, 12152–12160 (2015). (doi:10.1039/C4RA15682J)

[◀︎ Open Access] [Free PDF] [Overview]


Why p-Cymene? Conformational Effect in Asymmetric Hydrogenation of Aromatic Ketones with a η6-Arene/Ruthenium(II) Catalyst

Aki Matsuoka, Christian A. Sandoval, Masanobu Uchiyama, Ryoji Noyori, and Hiroshi Naka

Chem. Asian J. 10, 112–115 (2015). (doi: 10.1002/asia.201402979 )

[◀︎ Open Access] [Free PDF] [Overview]


One-Step Synthesis of Patterned Polymer Brushes by Photocatalytic Microcontact Printing
Friederike Kettling, Benjamin Vonhören, Jennifer A. Krings, Susumu Saito, and Bart Jan Ravoo
Chem. Commun., 51, 1027-1030 (2015). (doi: 10.1039/C4CC08646E)


Mechanism of Asymmetric Hydrogenation of Aromatic Ketones Catalyzed by a Combined System of Ru(π-CH2C(CH3)CH2)2(cod) and the Chiral sp2N/sp3NH Hybrid Linear N4 Ligand Ph-BINAN-H-Py
Hiroshi Nakatsuka, Tomoya Yamamura, Yoshihiro Shuto, Shinji Tanaka, Masahiro Yoshimura, and Masato Kitamura
J. Am. Chem. Soc. 137, 8138–8149 (2015). (doi: 10.1021/jacs.5b02350)


Asymmetric NaBH4 1,4-Reduction of C3-Disubstituted 2-Propenoates Catalyzed by a Diamidine Cobalt Complex
Yoshihiro Shuto, Tomoya Yamamura, Shinji Tanaka, Masahiro Yoshimura, and Masato Kitamura

ChemCatChem 7, 1547–1550 (2015). (doi: 10.1002/cctc.201500260)



Synthesis of Propylene from Renewable Allyl Alcohol by Photocatalytic Transfer Hydrogenolysis

Joaquim Caner, Zijun Liu, Yuki Takada, Akihiko Kudo, Hiroshi Naka, and Susumu Saito

Catal. Sci. Technol. 4, 4093–4098 (2014). (doi: 10.1039/C4CY00329B)[Overview]


Activation of Cellular Defense Mechanism by Organic-Inorganic Hybrid Molecules

Tomoya Fujie, Hiroshi Naka, Chika Yamamoto, Yasuhiro Shinkai, Yoshito Kumagai, and Toshiyuki Kaji

Yakugaku Zasshi 134, 813−815 (2014). (doi: 10.1248/yakushi.14-00017-8)

[◀︎ Open Access] [Free PDF]

Catalytic Fluoride Triggers Dehydrative Oxazolidinone Synthesis from CO2

Yuki Takada, Siong Wan Foo, Yusuke Yamazaki, and Susumu Saito

RSC Adv. 4, 50851-50857 (2014). (doi: 10.1039/C4RA09609F)[Overview]


Stereoselective Synthesis of cis,cis-Configured Vicinal Triamines

Adrian Schulte, Susumu Saito,and Bernhard Wünsch

Eur. J. Org. Chem., 26, 5749–5756 (2014). (doiI:10.1002/ejoc.201402685)


Bromolactamization: Key Step in the Stereoselective Synthesis of

Enantiomerically Pure, cis-Configured Perhydropyrroloquinoxalines

Adrian Schulte, XINGCI SITU,Susumu Saito, and Bernhard Wünsch

Chirality, 793–800 (2014). (doi:  10.1002/chir.22350)



Hydration of Terminal Alkynes Catalyzed by Water-Soluble Cobalt Porphyrin Complexes

Tadashi Tachinami, Takuho Nishimura, Richiro Ushimaru, Ryoji Noyori, and Hiroshi Naka 
J. Am. Chem. Soc. 135, 50−53 (2013). (
doi: 10.1021/ja310282t) [Overview]

Redox-Selective Generation of Aldehydes and H2 from Alcohols under Visible Light

Zijun Liu, Joaquim Caner, Akihiko Kudo, Hiroshi Naka, and Susumu Saito

Chem. Eur. J. 19, 9452–9456 (2013). (doi: 10.1002/chem.201301347) Highlighted in Synfacts [Overview]


Acetals of N,N-Dimethylformamides: Ambiphilic Behavior in Converting Carbon Dioxide to Dialkyl Carbonates

Yuki Takada, Aki Matsuoka, Ya Du, Hiroshi Naka, and Susumu Saito

Chem. Lett., 42, 146–147 (2013). (doi: 10.1246/cl.2013.146)[Overview]


Ethical Conduct in Chemical Research and Publishing

Ryoji Noyori and Joe P. Richmond

Adv. Synth. Catal., 355, 3–9 (2013). (doi: 10.1002/adsc.201201128) [Overview]


Facts are the Enemy of Truth—Reflections on Serendipitous Discovery and Unforeseen Developments in Asymmetric Catalysis

Ryoji Noyori

Angew. Chem. Int. Ed., 52, 79–92 (2013). (doi: 10.1002/anie.201205537) [Overview]


Dehydrative synthesis of chiral oxazolidinones catalyzed by alkali metal carbonates under low pressure of CO2

Siong Wan Foo, Yuki Takada,Yusuke Yamazaki, and Susumu Saito

Tetrahedron Lett., 54. 4717–4720 (2013). (doi: 10.1016/j.tetlet.2013.06.100)


Catalytic Hydrogenation of Unactivated Amides Enabled by Hydrogenation of Catalyst Precursor

Takashi Miura, Ingmar E. Held, Shunsuke Oishi, Masayuki Naruto, and Susumu Saito
Tetrahedron. Lett. 54, 2674–2678 (2013) DOI: 10.1016/j.tetlet.2013.03.047

The Dual Role of Ruthenium and Alkali Base Catalysts in Enabling a Conceptually New Shortcut to N-Unsubstituted Pyrroles through Unmasked ɑ-Amino Aldehydes

Kazuki Iida, Takashi Miura, Junki Ando, and Susumu Saito
Org. Lett. 15, 1436–1439 (2013). DOI: 10.1021/ol4001262

Reaction of an “Invisible” Frustrated N/B Lewis Pair with Dihydrogen

Sina Schwendemann, Shunsuke Oishi, Susumu Saito, Roland Fröhlich, Gerald Kehr, and Gerhard Erker
Chem Asian J., 8, 212–217 (2013). (doi: 10.1002/asia.201200776)


Asymmetric Hydrogenation of tert-Alkyl Ketones: DMSO Effect in Unification of Stereoisomeric Ruthenium Complexes

Tomoya Yamamura, Hiroshi Nakatsuka, Shinji Tanaka, and Masato Kitamura

Angew. Chem. Int. Ed. 52, 9313-9315 (2013). (doi: 10.1002/anie.201304408)


CpRu-catalyzed Asymmetric Dehydrative Allylation

Masato Kitamura, Kengo Miyata, Tomoaki Seki, Namdev Vatmurge, and Shinji Tanaka

Pure. Appl. Chem. 56, 1121-1132 (2013).(doi: 10.1351/PAC-CON-12-10-02)